Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

نویسندگان

  • Emmie de Wit
  • Andrea Marzi
  • Trenton Bushmaker
  • Doug Brining
  • Dana Scott
  • Juergen A. Richt
  • Thomas W. Geisbert
  • Heinz Feldmann
چکیده

The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.

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عنوان ژورنال:

دوره 21  شماره 

صفحات  -

تاریخ انتشار 2015